Electron Microscopy Data Bank

Download Map 3D View

CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-7909 binding at an allosteric site

Release date: April 17, 2024
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8w9a
Q-score: 0.591

Huang X, Wang K, Han J, Chen X, Wang Z, Wu T, Yu B, Zhao F, Wang X, Li H, Xie Z, Zhu X, Zhong W, Ren X

Structure (2024) [ Pubmed: 38582077 DOI: doi:10.1016/j.str.2024.03.007 ]

Sample:

Human pi3k-alpha (p85/p110-h1047r) with qr-7909 binding at an allosteric site (Complex from Homo sapiens)
Water (18 Da, Ligand)
Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (124 kDa, Protein from Homo sapiens)
6-chloranyl-3-[[(1r)-1-[2-(1,3-dihydropyrrolo[3,4-c]pyridin-2-yl)-3,6-dimethyl-4-oxidanylidene-quinazolin-8-yl]ethyl]amino]pyridine-2-carboxylic acid (490 Da, Ligand)

[Show more]

EMD-37363

Download Map 3D View

CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-8557 binding at an allosteric site

Release date: April 17, 2024
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8w9b
Q-score: 0.496

Huang X, Wang K, Han J, Chen X, Wang Z, Wu T, Yu B, Zhao F, Wang X, Li H, Xie Z, Zhu X, Zhong W, Ren X

Structure (2024) [ Pubmed: 38582077 DOI: doi:10.1016/j.str.2024.03.007 ]

Sample:

[Show more]

EMD-37104

Download Map 3D View

96-nm axonemal repeat with RS1/2/3

Release date: April 10, 2024
Resolution: 24.2 Å
EM Method: Subtomogram averaging

Meng X, Xu C, Li J, Qiu B, Luo J, Hong Q, Tong Y, Fang C, Feng Y, Ma R, Shi X, Lin C, Pan C, Zhu X, Yan X, Cong Y

Nat Commun (2024) 15 pp. 362-362 [ DOI: doi:10.1038/s41467-023-44577-1 Pubmed: 38191553 ]

Sample:

The ependymal cilia (Cellular component from Mus musculus)

EMD-37111

Download Map 3D View

48-nm repeat DMT

Release date: April 10, 2024
Resolution: 19.6 Å
EM Method: Subtomogram averaging

Meng X, Xu C, Li J, Qiu B, Luo J, Hong Q, Tong Y, Fang C, Feng Y, Ma R, Shi X, Lin C, Pan C, Zhu X, Yan X, Cong Y

Nat Commun (2024) 15 pp. 362-362 [ DOI: doi:10.1038/s41467-023-44577-1 Pubmed: 38191553 ]

Sample:

The ependymal cilia (Cellular component from Mus musculus)

EMD-37114

Download Map 3D View

Radial Spoke 1 (RS1)

Release date: April 10, 2024
Resolution: 25.0 Å
EM Method: Subtomogram averaging

Meng X, Xu C, Li J, Qiu B, Luo J, Hong Q, Tong Y, Fang C, Feng Y, Ma R, Shi X, Lin C, Pan C, Zhu X, Yan X, Cong Y

Nat Commun (2024) 15 pp. 362-362 [ DOI: doi:10.1038/s41467-023-44577-1 Pubmed: 38191553 ]

Sample:

The ependymal cilia (Cellular component from Mus musculus)

EMD-37116

Download Map 3D View

RS1 refined with head mask

Release date: April 10, 2024
Resolution: 25.0 Å
EM Method: Subtomogram averaging

Meng X, Xu C, Li J, Qiu B, Luo J, Hong Q, Tong Y, Fang C, Feng Y, Ma R, Shi X, Lin C, Pan C, Zhu X, Yan X, Cong Y

Nat Commun (2024) 15 pp. 362-362 [ DOI: doi:10.1038/s41467-023-44577-1 Pubmed: 38191553 ]

Sample:

The ependymal cilia (Cellular component from Mus musculus)

EMD-37117

Download Map 3D View

Radial Spoke 2 (RS2)

Release date: April 10, 2024
Resolution: 24.2 Å
EM Method: Subtomogram averaging

Meng X, Xu C, Li J, Qiu B, Luo J, Hong Q, Tong Y, Fang C, Feng Y, Ma R, Shi X, Lin C, Pan C, Zhu X, Yan X, Cong Y

Nat Commun (2024) 15 pp. 362-362 [ DOI: doi:10.1038/s41467-023-44577-1 Pubmed: 38191553 ]

Sample:

The ependymal cilia (Cellular component from Mus musculus)

EMD-37118

Download Map 3D View

Radial Spoke 2 (RS2) head

Release date: April 10, 2024
Resolution: 23.8 Å
EM Method: Subtomogram averaging

Meng X, Xu C, Li J, Qiu B, Luo J, Hong Q, Tong Y, Fang C, Feng Y, Ma R, Shi X, Lin C, Pan C, Zhu X, Yan X, Cong Y

Nat Commun (2024) 15 pp. 362-362 [ DOI: doi:10.1038/s41467-023-44577-1 Pubmed: 38191553 ]

Sample:

The ependymal cilia (Cellular component from Mus musculus)

EMD-37119

Download Map 3D View

Radial Spoke 3

Release date: April 10, 2024
Resolution: 27.0 Å
EM Method: Subtomogram averaging

Meng X, Xu C, Li J, Qiu B, Luo J, Hong Q, Tong Y, Fang C, Feng Y, Ma R, Shi X, Lin C, Pan C, Zhu X, Yan X, Cong Y

Nat Commun (2024) 15 pp. 362-362 [ DOI: doi:10.1038/s41467-023-44577-1 Pubmed: 38191553 ]

Sample:

The ependymal cilia (Cellular component from Mus musculus)

EMD-37120

Download Map 3D View

Radial Spoke 3 head

Release date: April 10, 2024
Resolution: 28.9 Å
EM Method: Subtomogram averaging

Meng X, Xu C, Li J, Qiu B, Luo J, Hong Q, Tong Y, Fang C, Feng Y, Ma R, Shi X, Lin C, Pan C, Zhu X, Yan X, Cong Y

Nat Commun (2024) 15 pp. 362-362 [ DOI: doi:10.1038/s41467-023-44577-1 Pubmed: 38191553 ]

Sample:

The ependymal cilia (Cellular component from Mus musculus)

Filter By

Filter By